| First Author | Nguyen LT | Year | 2002 |
| Journal | J Exp Med | Volume | 195 |
| Issue | 4 | Pages | 423-35 |
| PubMed ID | 11854356 | Mgi Jnum | J:338738 |
| Mgi Id | MGI:7514475 | Doi | 10.1084/jem.20010032 |
| Citation | Nguyen LT, et al. (2002) Tumor growth enhances cross-presentation leading to limited T cell activation without tolerance. J Exp Med 195(4):423-35 |
| abstractText | Using a tumor model of spontaneously arising insulinomas expressing a defined tumor-associated antigen, we investigated whether tumor growth promotes cross-presentation and tolerance of tumor-specific T cells. We found that an advanced tumor burden enhanced cross-presentation of tumor-associated antigens to high avidity tumor-specific T cells, inducing T cell proliferation and limited effector function in vivo. However, contrary to other models, tumor-specific T cells were not tolerized despite a high tumor burden. In fact, in tumor-bearing mice, persistence and responsiveness of adoptively transferred tumor-specific T cells were enhanced. Accordingly, a potent T cell-mediated antitumor response could be elicited by intravenous administration of tumor-derived peptide and agonistic anti-CD40 antibody or viral immunization and reimmunization. Thus, in this model, tumor growth promotes activation of high avidity tumor-specific T cells instead of tolerance. Therefore, the host remains responsive to T cell immunotherapy. |
