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Allele : Dmd<tm1Mok> dystrophin, muscular dystrophy; targeted mutation 1, Motoya Katsuki

Primary Identifier  MGI:2429942 Allele Type  Targeted
Attribute String  Null/knockout Gene  Dmd
Transmission  Germline Strain of Origin  129S/SvEv-Gpi1<c>
Is Recombinase  false Is Wild Type  false
molecularNote  Expression of three isoforms produced by the endogenous locus was disrupted by the replacement of exon 52 with a neomycin selection cassette. Western blot analysis showed that while both the 116 kD peripheral nerve and the 71 kD non-muscle isoforms were present in mutant mice, the 427 kD dystrophin, 260 kD retinal, and 140 kD isoforms were absent.
  • mutations:
  • Insertion,
  • Intragenic deletion
  • synonyms:
  • X<mdx52>,
  • X<mdx52>
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1 Feature

Trail: Allele

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

2 Carried By

Trail: Allele

0 Driven By

17 Publication categories

Trail: Allele