| First Author | Lee BH | Year | 2007 |
| Journal | Cancer Cell | Volume | 12 |
| Issue | 4 | Pages | 367-80 |
| PubMed ID | 17936561 | Mgi Jnum | J:126003 |
| Mgi Id | MGI:3760346 | Doi | 10.1016/j.ccr.2007.08.031 |
| Citation | Lee BH, et al. (2007) FLT3 mutations confer enhanced proliferation and survival properties to multipotent progenitors in a murine model of chronic myelomonocytic leukemia. Cancer Cell 12(4):367-80 |
| abstractText | Despite their known transforming properties, the effects of leukemogenic FLT3-ITD mutations on hematopoietic stem and multipotent progenitor cells and on hematopoietic differentiation are not well understood. We report a mouse model harboring an ITD in the murine Flt3 locus that develops myeloproliferative disease resembling CMML and further identified FLT3-ITD mutations in a subset of human CMML. These findings correlated with an increase in number, cell cycling, and survival of multipotent stem and progenitor cells in an ITD dose-dependent manner in animals that exhibited alterations within their myeloid progenitor compartments and a block in normal B cell development. This model provides insights into the consequences of constitutive signaling by an oncogenic tyrosine kinase on hematopoietic progenitor quiescence, function, and cell fate. |
