| First Author | Kaisho T | Year | 1997 |
| Journal | Science | Volume | 276 |
| Issue | 5311 | Pages | 412-5 |
| PubMed ID | 9103199 | Mgi Jnum | J:39568 |
| Mgi Id | MGI:86922 | Doi | 10.1126/science.276.5311.412 |
| Citation | Kaisho T, et al. (1997) The roles of gamma1 heavy chain membrane expression and cytoplasmic tail in IgG1 responses. Science 276(5311):412-5 |
| abstractText | In antibody responses, B cells switch from the expression of immunoglobulin (Ig) mu and delta heavy (H) chains to that of other Ig classes (alpha, gamma, or varepsilon), each with a distinct effector function. Membrane-bound forms of alpha, gamma, and varepsilon, but not mu and delta, have highly conserved cytoplasmic tails. Mutant mice unable to express membrane gamma1 H chains or producing tailless gamma1 H chains failed to generate efficient IgG1 responses and IgG1 memory. H chain membrane expression after class switching is thus required for these functions, and class switching equips the B cell antigen receptor with a regulatory cytoplasmic tail that naive B cells lack. |
