| First Author | Dogan I | Year | 2009 |
| Journal | Nat Immunol | Volume | 10 |
| Issue | 12 | Pages | 1292-9 |
| PubMed ID | 19855380 | Mgi Jnum | J:157741 |
| Mgi Id | MGI:4436835 | Doi | 10.1038/ni.1814 |
| Citation | Dogan I, et al. (2009) Multiple layers of B cell memory with different effector functions. Nat Immunol 10(12):1292-9 |
| abstractText | Memory B cells are at the center of longstanding controversies regarding the presence of antigen for their survival and their re-engagement in germinal centers after secondary challenge. Using a new mouse model of memory B cell labeling dependent on the cytidine deaminase AID, we show that after immunization with a particulate antigen, B cell memory appeared in several subsets, comprising clusters of immunoglobulin M-positive (IgM(+)) and IgG1(+) B cells in germinal center-like structures that persisted up to 8 months after immunization, as well as IgM(+) and IgG1(+) B cells with a memory phenotype outside of B cell follicles. After challenge, the IgG subset differentiated into plasmocytes, whereas the IgM subset reinitiated a germinal center reaction. This model, in which B cell memory appears in several layers with different functions, reconciles previous conflicting propositions. |
