| First Author | Jepsen K | Year | 2008 |
| Journal | Genes Dev | Volume | 22 |
| Issue | 6 | Pages | 740-5 |
| PubMed ID | 18347093 | Mgi Jnum | J:132982 |
| Mgi Id | MGI:3777491 | Doi | 10.1101/gad.1637108 |
| Citation | Jepsen K, et al. (2008) Cooperative regulation in development by SMRT and FOXP1. Genes Dev 22(6):740-5 |
| abstractText | A critical aspect of mammalian development involves the actions of dedicated repressors/corepressors to prevent unregulated gene activation programs that would initiate specific cell determination events. While the role of NCoR/SMRT corepressors in nuclear receptor actions is well documented, we here report that a previously unrecognized functional interaction between SMRT and a forkhead protein, FOXP1, is required for cardiac growth and regulation of macrophage differentiation. Our studies demonstrate that SMRT and FOXP1 define a functional biological unit required to orchestrate specific programs critical for mammalian organogenesis, linking developmental roles of FOX to a specific corepressor. |
