| First Author | Wang Y | Year | 2006 |
| Journal | Cancer Cell | Volume | 10 |
| Issue | 3 | Pages | 179-90 |
| PubMed ID | 16959610 | Mgi Jnum | J:112696 |
| Mgi Id | MGI:3663202 | Doi | 10.1016/j.ccr.2006.08.008 |
| Citation | Wang Y, et al. (2006) Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling. Cancer Cell 10(3):179-90 |
| abstractText | The genetic mechanisms responsible for increased incidence of lymphoma in immunocompromised individuals have not been fully elucidated. We show that, in a line of TCR transgenic TG-B mice, an insertional mutation in one allele of the Epm2a locus and epigenetic silencing of another led to a high rate of lymphoma with early onset. Overexpressing Epm2a suppressed the growth of established tumor cells and the development of lymphoma in the TG-B mice, while specific silencing of the locus increased tumorigenesis in the immune-deficient host. Downregulation of Epm2a expression is widespread among mouse and human lymphoma cell lines. Epm2a-encoded laforin is a phosphatase for GSK-3beta and an important repressor in the Wnt signaling pathway. Inactivation of Epm2a resulted in increased Wnt signaling and tumorigenesis. |
