| First Author | Urano F | Year | 2000 |
| Journal | Science | Volume | 287 |
| Issue | 5453 | Pages | 664-6 |
| PubMed ID | 10650002 | Mgi Jnum | J:132966 |
| Mgi Id | MGI:3777353 | Doi | 10.1126/science.287.5453.664 |
| Citation | Urano F, et al. (2000) Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287(5453):664-6 |
| abstractText | Malfolded proteins in the endoplasmic reticulum (ER) induce cellular stress and activate c-Jun amino-terminal kinases (JNKs or SAPKs). Mammalian homologs of yeast IRE1, which activate chaperone genes in response to ER stress, also activated JNK, and IRE1alpha-/- fibroblasts were impaired in JNK activation by ER stress. The cytoplasmic part of IRE1 bound TRAF2, an adaptor protein that couples plasma membrane receptors to JNK activation. Dominant-negative TRAF2 inhibited activation of JNK by IRE1. Activation of JNK by endogenous signals initiated in the ER proceeds by a pathway similar to that initiated by cell surface receptors in response to extracellular signals. |
