| First Author | Wang M | Year | 2005 |
| Journal | Exp Lung Res | Volume | 31 |
| Issue | 2 | Pages | 193-204 |
| PubMed ID | 15828125 | Mgi Jnum | J:98656 |
| Mgi Id | MGI:3579596 | Doi | 10.1080/01902140490495598 |
| Citation | Wang M, et al. (2005) Analysis of the Par2 modifier of pulmonary adenoma formation in mice. Exp Lung Res 31(2):193-204 |
| abstractText | Inbred strains of mouse show various susceptibilities to spontaneous and chemical-induced lung tumorigenesis. Genetic analyses have revealed that lung tumor susceptibilities of inbred mouse strains are governed by quantitative trait loci (QLTs) located on multiple chromosomes. A major lung tumor resistance QLT, designated pulmonary adenoma resistance 2 (Par2), was mapped to the mouse chromosome 18 independently by several groups and accounted for up to 60% phenotype variance between susceptible A/J and more resistant BALB/c strains. The authors recently conducted studies to positionally clone the Par2 gene. This review summarizes the effort and progress towards the identification of Par2 candidates. |
