| First Author | Nakamura Y | Year | 2018 |
| Journal | Cell Death Dis | Volume | 9 |
| Issue | 12 | Pages | 1181 |
| PubMed ID | 30518914 | Mgi Jnum | J:295125 |
| Mgi Id | MGI:6459667 | Doi | 10.1038/s41419-018-1226-1 |
| Citation | Nakamura Y, et al. (2018) Elovl6 regulates mechanical damage-induced keratinocyte death and skin inflammation. Cell Death Dis 9(12):1181 |
| abstractText | Mechanical damage on the skin not only affects barrier function but also induces various immune responses, which trigger or exacerbate skin inflammation. However, how mechanical damage-induced skin inflammation is regulated remains incompletely understood. Here, we show that keratinocytes express the long-chain fatty-acid elongase Elovl6. Mice deficient in Elovl6 showed higher levels of cis-vaccenic acid (CVA) in the epidermis and severe skin inflammation induced by mechanical damage due to tape stripping than did wild-type mice. CVA accelerated tape stripping-triggered keratinocyte death and release of danger-associated molecular patterns (DAMPs) such as high-mobility group box 1 protein (HMGB-1) and IL-1alpha, which induced production of proinflammatory cytokines and chemokines IL-1beta and CXCL-1 by keratinocytes. Our results demonstrate that Elovl6 regulates mechanical damage-triggered keratinocyte death and the subsequent dermatitis. |
