| First Author | Tada Y | Year | 2006 |
| Journal | Clin Immunol | Volume | 120 |
| Issue | 2 | Pages | 179-88 |
| PubMed ID | 16616645 | Mgi Jnum | J:144915 |
| Mgi Id | MGI:3832166 | Doi | 10.1016/j.clim.2006.02.009 |
| Citation | Tada Y, et al. (2006) Role of inducible costimulator in the development of lupus in MRL/lpr mice. Clin Immunol 120(2):179-88 |
| abstractText | Inducible costimulator (ICOS) is a costimulatory molecule expressed in activated T cells and plays an important role in T-cell-dependent immune responses. We investigated the role of ICOS in the development of autoimmune diseases in MRL/Mpj-lpr/lpr (MRL/lpr) mice. ICOS was expressed on CD4(+) T cells from adult MRL/lpr mice. ICOS-deficient MRL/lpr mice showed mild lymphoadenopathy and a decreased memory type CD4(+) T cells in the spleen. The anti-dsDNA antibody levels were decreased. CD4(+) T cells from ICOS-deficient MRL/lpr mice showed less of a bias to Th1 and an enhanced production of IL-4 in response to anti-CD3 antibody in comparison to those from wild-type MRL/lpr mice. Although ICOS-deficiency abrogated renal vasculitis completely, the severity of glomerulonephritis was not altered. ICOS is considered to play a role in CD4(+) T cell activation, autoantibody production, and renal vasculitis. However, it is not essentially required in the development of glomerulonephritis. |
