| First Author | Yoshida S | Year | 1991 |
| Journal | FEMS Microbiol Immunol | Volume | 4 |
| Issue | 1 | Pages | 51-6 |
| PubMed ID | 1815711 | Mgi Jnum | J:657 |
| Mgi Id | MGI:49193 | Doi | 10.1111/j.1574-6968.1991.tb04970.x |
| Citation | Yoshida S, et al. (1991) Association of Lps gene with natural resistance of mouse macrophages against Legionella pneumophila. FEMS Microbiol Immunol 4(1):51-6 |
| abstractText | Peritoneal macrophages obtained from lipopolysaccharide (LPS)-low responder C3H/HeJ mice (J) permitted the intracellular growth of the bacterium in macrophages of (J x N) F1 progeny was between the parent strains, showing that the traits were co-dominantly expressed. Correlation between intracellular bacterial growth in macrophages and LPS response of spleen cells was examined. Negative correlation was found between the two factors in F2, (J x F1) backcross and (N x F1) backcross progeny. This result implies that Lps gene controls the innate resistance of murine macrophages against the bacteria. Although macrophages of A/J strain also permit intracellular growth of L. pneumophila, gene complementation analysis of A/J and C3H/HeJ mice made clear that the gene control in C3H/HeJ differs from that of A/J strain. Macrophages of C57BL/10ScN, which is LPS-low responder line obtained from C57BL/10, were also defective in controlling the bacterial growth when compared to C57BL/10 mice. We suggest that the Lps gene also controls the natural resistance of murine macrophages against L. pneumophila. |
