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Publication : Role of Nramp1 deletion in Chlamydia infection in mice.

First Author  Pal S Year  2000
Journal  Infect Immun Volume  68
Issue  8 Pages  4831-3
PubMed ID  10899900 Mgi Jnum  J:63617
Mgi Id  MGI:1861296 Doi  10.1128/iai.68.8.4831-4833.2000
Citation  Pal S, et al. (2000) Role of Nramp1 deletion in Chlamydia infection in mice. Infect Immun 68(8):4831-3
abstractText  Elicited macrophages from 129sv mice with a functional deletion of the natural-resistance-associated macrophage protein 1 gene (Nramp1) were shown to be as susceptible as wild-type mice to infection with the Chlamydia trachomatis mouse pneumonitis and L3 serovars and to Chlamydia pneumoniae. Furthermore, the two groups of mice were shown to be similarly susceptible to an intranasal infection with these microorganisms. In conclusion, the Nramp1 gene does not appear to play a major role in the regulation of the susceptibility of mice to a chlamydial infection.
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