| First Author | Diaz-Perez S | Year | 2005 |
| Journal | Genetics | Volume | 171 |
| Issue | 2 | Pages | 663-72 |
| PubMed ID | 15972460 | Mgi Jnum | J:103500 |
| Mgi Id | MGI:3609591 | Doi | 10.1534/genetics.105.043026 |
| Citation | Diaz-Perez S, et al. (2005) The element(s) at the nontranscribed Xist locus of the active X chromosome controls chromosomal replication timing in the mouse. Genetics 171(2):663-72 |
| abstractText | In female mammalian cells, the inactive X chromosome is replicated late in S phase while the active X chromosome is replicated earlier. The replication times of the X chromosomes reflect a general trend in which late replication is associated with gene repression and earlier replication with transcriptional competence. The X-linked Xist gene is expressed exclusively from the inactive X chromosome where it is involved in the initiation and maintenance of X-inactivation. In contrast, no biological activity has been assigned to the Xist locus of the active X chromosome where the Xist gene is transcriptionally silenced. Here, we provide evidence that the element(s) at the nontranscribed Xist locus of the active X chromosome controls chromosomal replication timing in cis. |
