| Primary Identifier | MGI:2445463 | Allele Type | Targeted |
| Attribute String | Null/knockout, Reporter | Gene | Ncoa6 |
| Transmission | Germline | Strain of Origin | 129S6/SvEvTac |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | A 21.4 kb sequence fragment containing exons 4, 5, and 6 and encoding amino acids 171 through 895 was replaced by a cassette containing lacZ and neo. While the translation of a truncated amino terminal peptide was anticipated, no normal protein was detected in homozygous mutant mice using a carboxyl terminal antibody. The predicted truncated peptide putatively lacked domains necessary for interactions with transcription factors, DNA dependent protein kinases, and other protein complexes. |
