| First Author | Zhou X | Year | 2022 |
| Journal | Cell Rep | Volume | 39 |
| Issue | 5 | Pages | 110750 |
| PubMed ID | 35508129 | Mgi Jnum | J:337696 |
| Mgi Id | MGI:7283983 | Doi | 10.1016/j.celrep.2022.110750 |
| Citation | Zhou X, et al. (2022) SM22alpha-lineage niche cells regulate intramembranous bone regeneration via PDGFRbeta-triggered hydrogen sulfide production. Cell Rep 39(5):110750 |
| abstractText | Bone stromal cells are critical for bone homeostasis and regeneration. Growing evidence suggests that non-stem bone niche cells support bone homeostasis and regeneration via paracrine mechanisms, which remain to be elucidated. Here, we show that physiologically quiescent SM22alpha-lineage stromal cells expand after bone injury to regulate diverse processes of intramembranous bone regeneration. The majority of SM22alpha-lineage cells neither act as stem cells in vivo nor show their expression patterns. Dysfunction of SM22alpha-lineage niche cells induced by loss of platelet-derived growth factor receptor beta (PDGFRbeta) impairs bone repair. We further show that PDGFRbeta-triggered hydrogen sulfide (H2S) generation in SM22alpha-lineage niche cells facilitates osteogenesis and angiogenesis and suppresses overactive osteoclastogenesis. Collectively, these data demonstrate that non-stem SM22alpha-lineage niche cells support the niche for bone regeneration with a PDGFRbeta/H2S-dependent regulatory mechanism. Our findings provide further insight into non-stem bone stromal niche cell populations and niche-regulation strategy for bone repair. |
