|  Help  |  About  |  Contact Us

Publication : Patch repair of deep wounds by mobilized fascia.

First Author  Correa-Gallegos D Year  2019
Journal  Nature Volume  576
Issue  7786 Pages  287-292
PubMed ID  31776510 Mgi Jnum  J:293246
Mgi Id  MGI:6445702 Doi  10.1038/s41586-019-1794-y
Citation  Correa-Gallegos D, et al. (2019) Patch repair of deep wounds by mobilized fascia. Nature 576(7786):287-292
abstractText  Mammals form scars to quickly seal wounds and ensure survival by an incompletely understood mechanism(1-5). Here we show that skin scars originate from prefabricated matrix in the subcutaneous fascia. Fate mapping and live imaging revealed that fascia fibroblasts rise to the skin surface after wounding, dragging their surrounding extracellular jelly-like matrix, including embedded blood vessels, macrophages and peripheral nerves, to form the provisional matrix. Genetic ablation of fascia fibroblasts prevented matrix from homing into wounds and resulted in defective scars, whereas placing an impermeable film beneath the skin-preventing fascia fibroblasts from migrating upwards-led to chronic open wounds. Thus, fascia contains a specialized prefabricated kit of sentry fibroblasts, embedded within a movable sealant, that preassemble together diverse cell types and matrix components needed to heal wounds. Our findings suggest that chronic and excessive skin wounds may be attributed to the mobility of the fascia matrix.
Quick Links:
 
Quick Links:
 

Expression

Publication --> Expression annotations

 

Other

8 Bio Entities

Trail: Publication

0 Expression