| Primary Identifier | MGI:2446468 | Allele Type | Targeted |
| Attribute String | Conditional ready, Null/knockout | Gene | Trrap |
| Transmission | Germline | Strain of Origin | 129P2/OlaHsd |
| Is Recombinase | false | Is Wild Type | false |
| description | No mice derived from ES cells bearing the "floxed" allele from which only the neo-tk cassette had been deleted were recovered. |
| molecularNote | The exon encoding the beginning of the protein's kinase-like domain was deleted via in vitro Cre-mediated recombination in targeted ES cells between a single upstream loxP site and the 3' loxP site of a downstream loxP-flanked neor-tk cassette. The absence of homozygous progeny from crosses of mice heterozygous for this allele demonstrates functional disruption of the gene or protein. |
