| First Author | Takasawa S | Year | 2006 |
| Journal | FEBS Lett | Volume | 580 |
| Issue | 2 | Pages | 585-91 |
| PubMed ID | 16405968 | Mgi Jnum | J:105537 |
| Mgi Id | MGI:3615755 | Doi | 10.1016/j.febslet.2005.12.070 |
| Citation | Takasawa S, et al. (2006) Cyclin D1 activation through ATF-2 in Reg-induced pancreatic beta-cell regeneration. FEBS Lett 580(2):585-91 |
| abstractText | Regenerating gene product (Reg) is induced in pancreatic beta-cells and acts as an autocrine/paracrine growth factor for regeneration via a cell surface Reg receptor. However, the manner by which Reg induces beta-cell regeneration was unknown. In the present study, we found that Reg increased phospho-ATF-2, which binds to -57 to -52 of the cyclin D1 gene to activate the promoter. The Reg/ATF-2-induced cyclin D1 promoter activation was attenuated by PI(3)K inhibitors such as LY294002 and wortmannin. In Reg knockout mouse islets, the levels of phospho-ATF-2, cyclin D1, and phospho-Rb were greatly decreased. These results indicate that the Reg-Reg receptor system stimulates the PI(3)K/ATF-2/cyclin D1 signaling pathway to induce beta-cell regeneration. |
