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Publication : Decreased locomotor activity in mice carrying transgenic Fyn tyrosine kinase.

First Author  Ishibashi H Year  2000
Journal  Biochem Biophys Res Commun Volume  276
Issue  2 Pages  707-9
PubMed ID  11027535 Mgi Jnum  J:64803
Mgi Id  MGI:1889997 Doi  10.1006/bbrc.2000.3534
Citation  Ishibashi H, et al. (2000) Decreased locomotor activity in mice carrying transgenic fyn tyrosine kinase. Biochem Biophys Res Commun 276(2):707-9
abstractText  We found that mice carrying constitutively active Fyn tyrosine kinase show low levels of spontaneous locomotor activity and that this activity increases when the mice are treated with the NMDA receptor antagonist MK-801. These findings indicate that the tyrosine phosphorylation of the NMDA receptors by Fyn participates in the control of locomotor activity. Copyright 2000 Academic Press.
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