| Primary Identifier | MGI:2446663 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Prnp)46Jcol |
| Strain of Origin | mixed | Is Recombinase | false |
| Is Wild Type | false |
| description | The founder line contained 1 copy of the transgenic construct. Eggs of mixed background involve: 129/Sv * C57BL * FVB/N. |
| molecularNote | A transgenic construct was generated by inserting the Prnp open reading frame flanked by loxP sites into a cosmid vector. The regulatory sequences contained within cosmid CosSHaTet drove expression in the brain, spinal cord, peripheral nerve, and spleen. Expression levels were determined to be similar to wild-type by semi-quantitative Western blot analysis. |
