| First Author | Mach N | Year | 1998 |
| Journal | Blood | Volume | 91 |
| Issue | 3 | Pages | 778-83 |
| PubMed ID | 9446636 | Mgi Jnum | J:80640 |
| Mgi Id | MGI:2446539 | Citation | Mach N, et al. (1998) Involvement of interleukin-3 in delayed-type hypersensitivity. Blood 91(3):778-83 |
| abstractText | The in vivo functions of interleukin-3 (IL-3) were investigated by generating IL-3-deficient mice. Although hematopoiesis was unimpaired in homozygous mutant animals, contact hypersensitivity reactions were compromised. IL-3 was required for efficient priming of hapten-specific contact hypersensitivity responses, but was dispensable for T-cell-dependent sensitization to tumor cells. These findings reveal a critical role for IL-3 in some forms of delayed-type hypersensitivity. |
