| First Author | Karapetyan YE | Year | 2009 |
| Journal | PLoS One | Volume | 4 |
| Issue | 5 | Pages | e5730 |
| PubMed ID | 19478942 | Mgi Jnum | J:148835 |
| Mgi Id | MGI:3847002 | Doi | 10.1371/journal.pone.0005730 |
| Citation | Karapetyan YE, et al. (2009) Prion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assay. PLoS One 4(5):e5730 |
| abstractText | Prion strain identification has been hitherto achieved using time-consuming incubation time determinations in one or more mouse lines and elaborate neuropathological assessment. In the present work, we make a detailed study of the properties of PrP-overproducing Tga20 mice. We show that in these mice the four prion strains examined are rapidly and faithfully amplified and can subsequently be discriminated by a cell-based procedure, the Cell Panel Assay. |
