| First Author | Saito T | Year | 2014 |
| Journal | Nat Neurosci | Volume | 17 |
| Issue | 5 | Pages | 661-3 |
| PubMed ID | 24728269 | Mgi Jnum | J:212758 |
| Mgi Id | MGI:5582124 | Doi | 10.1038/nn.3697 |
| Citation | Saito T, et al. (2014) Single App knock-in mouse models of Alzheimer's disease. Nat Neurosci 17(5):661-3 |
| abstractText | Experimental studies of Alzheimer's disease have largely depended on transgenic mice overexpressing amyloid precursor protein (APP). These mice, however, suffer from artificial phenotypes because, in addition to amyloid beta peptide (Abeta), they overproduce other APP fragments. We generated knock-in mice that harbor Swedish and Beyreuther/Iberian mutations with and without the Arctic mutation in the APP gene. The mice showed typical Abeta pathology, neuroinflammation and memory impairment in an age-dependent manner. |
