Other
16 Authors
- Shi X,
- Tadokoro K,
- Ohta Y,
- Nomura E,
- Liu X,
- Nakano Y,
- Tian F,
- Li X,
- Hishikawa N,
- Tsunoda K,
- Sato K,
- Shang J,
- Abe K,
- Yamashita T,
- Takemoto M,
- Sasaki R
| First Author | Shang J | Year | 2019 |
| Journal | Brain Res | Volume | 1723 |
| Pages | 146379 | PubMed ID | 31415766 |
| Mgi Jnum | J:282167 | Mgi Id | MGI:6380377 |
| Doi | 10.1016/j.brainres.2019.146379 | Citation | Shang J, et al. (2019) Chronic cerebral hypoperfusion alters amyloid-beta transport related proteins in the cortical blood vessels of Alzheimer's disease model mouse. Brain Res 1723:146379 |
| abstractText | Abnormal accumulation of amyloid-beta (Abeta) peptide defines progression of Alzheimer's disease (AD) pathology in brain. Here, we investigated expressive changes of two main Abeta transport receptors low-density lipoprotein receptor related protein-1 (LRP1) and receptor for advanced glycation end products (RAGE) in a novel AD mice (APP23) with chronic cerebral hypoperfusion (CCH) model, moreover, examined a protective effect of a free radical scavenger edaravone (Eda). In contrast to wild type (WT) and APP23 mice, CCH strongly accelerated abnormal Abeta40 depositions and cerebral amyloid angiopathy (CAA) pathology, increased both LRP1 and RAGE expressions in brain parenchyma, while a decrease of LRP1 and an increase of RAGE were observed in vascular endothelial cells at age 12months (M) of AD mice. Furthermore, CCH strongly increased expressions of two hypoxia-related proteins hypoxia inducible factor-1alpha (HIF-1alpha) and heme oxygenase-1 (HO-1), two oxidative-related proteins 4-hydroxy-2-nonenal (4-HNE) and 8-hydroxy-2'-deoxyguanosine (8-OHdG), and decreased both two vital nutrient transporter proteins major facilitator super family domain containing 2a (Mfsd2a) and glucose transporter 1 (Glut1) expressions. Such the above abnormal pathological changes were significantly ameliorated by edaravone treatment. The present study demonstrated that CCH strongly enhanced primary AD pathology causing double imbalances of Abeta efflux and influx transport related proteins in the cortical blood vessels in AD mice, and that such a neuropathologic abnormality was greatly ameliorated by Eda. |
