| First Author | Vloeberghs E | Year | 2006 |
| Journal | Neurosci Lett | Volume | 407 |
| Issue | 1 | Pages | 6-10 |
| PubMed ID | 16959424 | Mgi Jnum | J:112638 |
| Mgi Id | MGI:3662957 | Doi | 10.1016/j.neulet.2006.07.060 |
| Citation | Vloeberghs E, et al. (2006) APP23 mice display working memory impairment in the plus-shaped water maze. Neurosci Lett 407(1):6-10 |
| abstractText | Alzheimer's disease (AD) patients typically present short-term memory deficits, before long-term memory capacity declines with disease progression. Several studies have described learning and memory deficits in the APP23 mouse model. Our group reported a decline of learning and memory capacities from the age of 3 months onwards using a hidden-platform Morris water maze (MWM). The aim of the present study was to evaluate working and reference memory in APP23 mice in the same plus-shaped water maze. The transgenic mice had slower learning curves; however, consolidation of the learned information appeared intact in this learning paradigm. This report demonstrates impairment of working memory in this transgenic Alzheimer model. |
