| First Author | Van Acker ZP | Year | 2017 |
| Journal | FEBS Lett | Volume | 591 |
| Issue | 10 | Pages | 1321-1332 |
| PubMed ID | 28391636 | Mgi Jnum | J:243354 |
| Mgi Id | MGI:5908294 | Doi | 10.1002/1873-3468.12651 |
| Citation | Van Acker ZP, et al. (2017) Impaired hypoxic tolerance in APP23 mice: a dysregulation of neuroprotective globin levels. FEBS Lett 591(10):1321-1332 |
| abstractText | Although neuroglobin confers neuroprotection against Alzheimer's disease (AD) pathology, its expression becomes downregulated in late-stage AD. Here, we provide evidence that indicates that this decrease is associated with the AD-linked angiopathy. While wild-type mice of different ages show upregulated cerebral neuroglobin expression upon whole-body hypoxia, APP23 mice exhibit decreased cerebral transcription of neuroglobin. Interestingly, transcription of cytoglobin, whose involvement in amyloid pathology still needs to be elucidated, follows a similar pattern. To further unravel the underlying mechanism, we examined the expression levels of the RE-1-silencing transcription factor (REST/NRSF) after identifying a recognition site for it in the regulatory region of both globins. Neuroglobin-cytoglobin-REST/NRSF expression correlations are detected mainly in the cortex. This raises the possibility of REST/NRSF being an upstream regulator of these globins. |
