| First Author | Asa SL | Year | 1990 |
| Journal | Proc Soc Exp Biol Med | Volume | 193 |
| Issue | 3 | Pages | 232-5 |
| PubMed ID | 2106141 | Mgi Jnum | J:91172 |
| Mgi Id | MGI:3046068 | Doi | 10.3181/00379727-193-3-rc1 |
| Citation | Asa SL, et al. (1990) Pituitary mammosomatotroph adenomas develop in old mice transgenic for growth hormone-releasing hormone. Proc Soc Exp Biol Med 193(3):232-5 |
| abstractText | It has been shown that mice transgenic for human growth hormone-releasing hormone (GRH) develop hyperplasia of pituitary somatotrophs and mammosomatotrophs, cells capable of producing both growth hormone and prolactin, by 8 months of age. We now report for the first time that old GRH-transgenic mice, 16 to 24 months of age, develop pituitary mammosomatotroph adenomas. These findings provide conclusive evidence that protracted stimulation of secretory activity can cause proliferation, hyperplasia and adenoma of adenohypophysial cells. |
