| First Author | Sun X | Year | 2014 |
| Journal | Cell Rep | Volume | 6 |
| Issue | 2 | Pages | 264-70 |
| PubMed ID | 24440716 | Mgi Jnum | J:208793 |
| Mgi Id | MGI:5565040 | Doi | 10.1016/j.celrep.2013.12.028 |
| Citation | Sun X, et al. (2014) miR-342-5p decreases ankyrin G levels in Alzheimer's disease transgenic mouse models. Cell Rep 6(2):264-70 |
| abstractText | MicroRNA alterations and axonopathy have been reported in patients with Alzheimer's disease (AD) and in AD mouse models. We now report that miR-342-5p is upregulated in APP/PS1, PS1DeltaE9, and PS1-M146V transgenic AD mice, and that this upregulation is mechanistically linked to elevated beta-catenin, c-Myc, and interferon regulatory factor-9. The increased miR-342-5p downregulates the expression of ankyrin G (AnkG), a protein that is known to play a critical role at the axon initial segment. Thus, a specific miRNA alteration may contribute to AD axonopathy by downregulating AnkG. |
