| First Author | Nikolajsen GN | Year | 2011 |
| Journal | Neurobiol Aging | Volume | 32 |
| Issue | 11 | Pages | 1927-31 |
| PubMed ID | 21752495 | Mgi Jnum | J:176689 |
| Mgi Id | MGI:5292440 | Doi | 10.1016/j.neurobiolaging.2011.05.006 |
| Citation | Nikolajsen GN, et al. (2011) Cholinergic axon length reduced by 300 meters in the brain of an Alzheimer mouse model. Neurobiol Aging 32(11):1927-31 |
| abstractText | Modern stereological techniques have been used to show that the total length of the cholinergic fibers in the cerebral cortex of the APPswe/PS1deltaE9 mouse is reduced by almost 300 meters at 18 months of age and has a nonlinear relationship to the amount of transgenetically-induced amyloidosis. These data provide rigorous quantitative morphological evidence that Alzheimer's-like amyloidosis affects the axons of the cholinergic enervation of the cerebral cortex. |
