| First Author | Ye SK | Year | 1999 |
| Journal | Immunity | Volume | 11 |
| Issue | 2 | Pages | 213-23 |
| PubMed ID | 10485656 | Mgi Jnum | J:57269 |
| Mgi Id | MGI:1344159 | Doi | 10.1016/s1074-7613(00)80096-5 |
| Citation | Ye SK, et al. (1999) Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor. Immunity 11(2):213-23 |
| abstractText | IL-7 receptor (IL-7R) plays critical roles in lymphocyte development by promoting survival and proliferation and by inducing V(D)J recombination in TCR and Ig loci. Here, we demonstrate that IL-7R-activated Stat5 binds to consensus motifs in the 5' regions of Jgamma segments and induces germline transcripts. We also show that a constitutively active form of Stat5 restores V-J recombination of TCRgamma genes and partially rescues T cell development from IL-7R(-/-) T cell precursors, especially in favor of gammadelta T cells. Therefore, this study reveals a potential role of Stat5 in T cell development and also implies that IL-7R may control the accessibility of the TCRgamma locus through Stat5-induced germline transcription. |
