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Allele : Tg(LCKprBCL2)36Sjk transgene insertion 36, Stanley J Korsmeyer
Primary Identifier  MGI:2447592 Allele Type  Transgenic
Attribute String  Humanized sequence, Inserted expressed sequence Gene  Tg(LCKprBCL2)36Sjk
Strain of Origin  Not Specified Is Recombinase  false
Is Wild Type  false
molecularNote  The transgene consists of 0.75 kb of Lck proximal promoter sequences (active in lymphoid tissues) and 3.2 kb of human BCL2 cDNA. Introns, exons, and polyadenylation sequences from the human growth hormone gene consitutes the 3' untranslated region of the construct. Transgene expression in the thymus, lymph nodes, and spleen was verified by Western blot analysis and immunohistochemistry. Seven transgenic lines were established with lines 7, 17, and 36 expressing the transgene at high levels.
  • mutations:
  • Insertion
  • synonyms:
  • lck<pr>-bcl-2,
  • Lck-BCL2,
  • prLck.hbcl-2,
  • prLck.hbcl-2,
  • Lck-Bcl-2,
  • lck<pr>-bcl-2,
  • Lck-Bcl-2,
  • Lck-BCL2
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