| First Author | Van de Wiele CJ | Year | 2007 |
| Journal | Cell Immunol | Volume | 250 |
| Issue | 1-2 | Pages | 31-9 |
| PubMed ID | 18321477 | Mgi Jnum | J:133580 |
| Mgi Id | MGI:3778863 | Doi | 10.1016/j.cellimm.2008.01.002 |
| Citation | Van de Wiele CJ, et al. (2007) Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2. Cell Immunol 250(1-2):31-9 |
| abstractText | Murine thymocytes down-regulate IL-7 responsiveness following beta-selection and reacquire sensitivity after positive selection. To assess the potential consequences of IL-7 signaling during this phase of development, transgenic IL-7 receptor alpha (IL-7Ralpha) mice were evaluated for IL-7 responsiveness as gauged by STAT-5 phosphorylation. Transgenic IL-7Ralpha expression increased the percentage of thymocytes responsive to IL-7 yet resulted in a decrease in total thymic cellularity. Aberrant thymocyte development in transgenic mice was first manifested by a reduction of DN3 thymocytes that correlated with lower Bcl-2 expression. Surprisingly, transgenic restoration of Bcl-2 expression did not correct thymic hypocellularity induced by IL-7Ralpha overexpression. These findings demonstrate that failure to appropriately downregulate IL-7Ralpha expression interferes with thymocyte development past the pro-T stage resulting in significantly lower levels of mature thymocytes. |
