| Primary Identifier | MGI:2447594 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(PDGFB-APOE)1Viz |
| Strain of Origin | C57BL/6 | Is Recombinase | false |
| Is Wild Type | false |
| molecularNote | A 4.9 kb genomic fragment containing exons 1 through 4 of the human APOE gene was adjoined to a 1.4 kb human PDGFB promoter fragment. Epsilon 2 (APOE2) was identified at both the mRNA and protein levels by RNase protection and Western blot analysis of transgenic brain tissue. Immunohistochemical analysis further localized the transgenic expression to hippocampal neurons. |
