| First Author | Cardone M | Year | 2005 |
| Journal | Mol Cell Biol | Volume | 25 |
| Issue | 6 | Pages | 2395-405 |
| PubMed ID | 15743832 | Mgi Jnum | J:97664 |
| Mgi Id | MGI:3575994 | Doi | 10.1128/MCB.25.6.2395-2405.2005 |
| Citation | Cardone M, et al. (2005) The novel ETS factor TEL2 cooperates with Myc in B lymphomagenesis. Mol Cell Biol 25(6):2395-405 |
| abstractText | The human ETS family gene TEL2/ETV7 is highly homologous to TEL1/ETV6, a frequent target of chromosome translocations in human leukemia and specific solid tumors. Here we report that TEL2 augments the proliferation and survival of normal mouse B cells and dramatically accelerates lymphoma development in Emu-Myc transgenic mice. Nonetheless, inactivation of the p53 pathway was a hallmark of all TEL2/Emu-Myc lymphomas, indicating that TEL2 expression alone is insufficient to bypass this apoptotic checkpoint. Although TEL2 is infrequently up-regulated in human sporadic Burkitt's lymphoma, analysis of pediatric B-cell acute lymphocytic leukemia (B-ALL) samples showed increased coexpression of TEL2 and MYC and/or MYCN in over one-third of B-ALL patients. Therefore, TEL2 and MYC also appear to cooperate in provoking a cadre of human B-cell malignancies. |
