| First Author | Langdon WY | Year | 1986 |
| Journal | Cell | Volume | 47 |
| Issue | 1 | Pages | 11-8 |
| PubMed ID | 3093082 | Mgi Jnum | J:81131 |
| Mgi Id | MGI:2448109 | Doi | 10.1016/0092-8674(86)90361-2 |
| Citation | Langdon WY, et al. (1986) The c-myc oncogene perturbs B lymphocyte development in E-mu-myc transgenic mice. Cell 47(1):11-8 |
| abstractText | Transgenic mice bearing a c-myc oncogene subjugated to the lymphoid-specific immunoglobulin heavy chain enhancer (E mu) develop clonal B lymphoid malignancies, but most young E mu-myc mice lack malignant clones. Their prelymphomatous state has allowed us to examine how constitutive c-myc expression influences B cell development. We find that early stages are overrepresented, even before birth. Pre-B cells of polyclonal origin increase greatly, while B cells develop in reduced number. Both the pre-B and the B cells appear to be in an active state, since they are larger than normal and a greater fraction are in the cell cycle. Enforced myc expression has thus favored proliferation over maturation. Hence, a normal function of c-myc may be to regulate differentiation as well as to promote cell cycling. |
