| First Author | Vandenberg CJ | Year | 2016 |
| Journal | Cell Death Dis | Volume | 6 |
| Pages | e2046 | PubMed ID | 26764572 |
| Mgi Jnum | J:320944 | Mgi Id | MGI:6882873 |
| Doi | 10.1038/cddis.2015.396 | Citation | Vandenberg CJ, et al. (2016) FoxO3 suppresses Myc-driven lymphomagenesis. Cell Death Dis 6:e2046 |
| abstractText | This study demonstrates, for the first time, that loss of a single forkhead box class O (FoxO) transcription factor, can promote lymphomagenesis. Using two different mouse models, we show that FoxO3 has a significant tumour-suppressor function in the context of Myc-driven lymphomagenesis. Loss of FoxO3 significantly accelerated myeloid tumorigenesis in vavP-MYC10 transgenic mice and B lymphomagenesis in Emu-myc transgenic mice. Tumour analysis indicated that the selective pressure for mutation of the p53 pathway during Emu-myc lymphomagenesis was not altered. Frank tumours were preceded by elevated macrophage numbers in FoxO3(-/-) vavP-MYC10 mice but, surprisingly, pre-B-cell numbers were relatively normal in healthy young FoxO3(-/-)Emu-myc mice. In vitro assays revealed enhanced survival capacity of Myc-driven cells lacking FoxO3, but no change in cell cycling was detected. The loss of FoxO3 may also be affecting other tumour-suppressive functions for which FoxO1/4 cannot fully compensate. |
