| First Author | Ferrad M | Year | 2020 |
| Journal | Front Immunol | Volume | 11 |
| Pages | 1564 | PubMed ID | 32793219 |
| Mgi Jnum | J:307927 | Mgi Id | MGI:6726712 |
| Doi | 10.3389/fimmu.2020.01564 | Citation | Ferrad M, et al. (2020) Mouse Models of c-myc Deregulation Driven by IgH Locus Enhancers as Models of B-Cell Lymphomagenesis. Front Immunol 11:1564 |
| abstractText | Chromosomal translocations linking various oncogenes to transcriptional enhancers of the immunoglobulin heavy chain (IgH) locus are often implicated as the cause of B-cell malignancies. Two major IgH transcriptional enhancers have been reported so far. The Emu enhancer located upstream of the Cmu gene controls early events in B-cell maturation such as VDJ recombination. The 3' regulatory region (3'RR) located downstream from the Calpha gene controls late events in B-cell maturation such as IgH transcription, somatic hypermutation, and class switch recombination. Convincing demonstrations of the essential contributions of both Emu and 3'RR in B-cell lymphomagenesis have been provided by transgenic and knock-in animal models which bring the oncogene c-myc under Emu/3'RR transcriptional control. This short review summarizes the different mouse models so far available and their interests/limitations for progress in our understanding of human c-myc-induced B-cell lymphomagenesis. |
