| First Author | Filali M | Year | 2009 |
| Journal | Genes Brain Behav | Volume | 8 |
| Issue | 2 | Pages | 143-8 |
| PubMed ID | 19077180 | Mgi Jnum | J:142183 |
| Mgi Id | MGI:3820520 | Doi | 10.1111/j.1601-183X.2008.00453.x |
| Citation | Filali M, et al. (2008) Cognitive and non-cognitive behaviors in an APPswe/PS1 bigenic model of Alzheimer's disease. Genes Brain Behav 8(2):143-8 |
| abstractText | Neuropsychiatric signs are critical in primary caregiving of Alzheimer patients and yet have been relatively ignored in murine models. In the present study, APPswe/PS1 bigenic mice had higher levels of irritability than non-transgenic controls as measured in the touch escape test. Moreover, APPswe/PS1 mice showed poorer nest building than controls and a higher duration of immobility in the forced swimming assay. These results are concordant with the hypothesis of increased apathy and depression-like behavior in an AD model. In addition, APPswe/PS1 bigenic mice were deficient in retention of passive avoidance learning and left-right discrimination learning, concordant with previous findings in other Alzheimer-like models. |
