| First Author | Scott L | Year | 2012 |
| Journal | Neurobiol Aging | Volume | 33 |
| Issue | 7 | Pages | 1481.e13-23 |
| PubMed ID | 22227005 | Mgi Jnum | J:188311 |
| Mgi Id | MGI:5440153 | Doi | 10.1016/j.neurobiolaging.2011.12.010 |
| Citation | Scott L, et al. (2012) Age-dependent disruption in hippocampal theta oscillation in amyloid-beta overproducing transgenic mice. Neurobiol Aging 33(7):1481.e13-23 |
| abstractText | Transgenic mice are used to model increased brain amyloid-beta (Abeta) and amyloid plaque formation reflecting Alzheimer's disease pathology. In our study hippocampal network oscillations, population spikes, and long-term potentiation (LTP) were recorded in APPswe/PS1dE9 (APP/PS1) and presenilin1 (PS1) transgenic and wild type mice at 2, 4, and 8 months of age under urethane anesthesia. Hippocampal theta oscillations elicited by brainstem stimulation were similar in wild type and PS1 mice at all age groups. In contrast, APP/PS1 mice showed an age-dependent decrease in hippocampal activity, characterized by a significant decline in elicited theta power and frequency at 4 and 8 months. Magnitudes of population spikes and long-term potentiation in the dentate gyrus were similar across groups at both 4 and 8 months. In APP/PS1 mice, soluble and insoluble Abeta, and hippocampal and cortical plaque load increased with age, and the disruption in hippocampal theta oscillation showed a significant correlation with plaque load. Our study shows that, using in vivo electrophysiological methods, early Abeta-related functional deficits can be robustly detected in the brainstem-hippocampus multisynaptic network. |
