| Primary Identifier | MGI:2447707 | Allele Type | Targeted |
| Attribute String | Conditional ready, No functional change | Gene | Smarcb1 |
| Transmission | Germline | Strain of Origin | 129S1/Sv-Oca2<+> Tyr<+> Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| description | Phenotypic Similarity to Human Syndrome: Atypical Teratoid/Rhabdoid Tumor of the Central Nervous System (Malignant Rhabdoid Tumors) J:226786 in double homozygous Smarcb1 and Trp53 conditional (Tg(GFAP-cre)#Gtm) mutants. |
| molecularNote | A loxP-flanked neomycin selection cassette was inserted into intron 1 and a single loxP site in the same orientation was inserted 0.8 kb upstream of exon 1. The neomycin selection cassette was removed by transient Cre expression in ES cells, leaving loxP sites flanking exon 1 in the final allele. Upon Cre-mediated recombination, exon 1 and flanking sequences are deleted. |
