| First Author | Tomiyama K | Year | 2009 |
| Journal | Prog Neuropsychopharmacol Biol Psychiatry | Volume | 33 |
| Issue | 2 | Pages | 330-3 |
| PubMed ID | 19150478 | Mgi Jnum | J:150617 |
| Mgi Id | MGI:3851076 | Doi | 10.1016/j.pnpbp.2008.12.010 |
| Citation | Tomiyama K, et al. (2009) Phenotype of spontaneous orofacial dyskinesia in neuregulin-1 'knockout' mice. Prog Neuropsychopharmacol Biol Psychiatry 33(2):330-3 |
| abstractText | Studies in antipsychotic-naive patients with schizophrenia indicate a baseline level of spontaneous involuntary movements, particularly orofacial dyskinesia. Neuregulin-1 is associated with risk for schizophrenia and its functional role can be studied in 'knockout' mice. We have shown previously that neuregulin-1 'knockouts' evidence disruption in social behaviour. Neuregulin-1 'knockouts' were assessed for four topographies of orofacial movement, both spontaneously and under challenge with the D(1)-like dopamine receptor agonist SKF 83959. Neuregulin-1 'knockouts' evidenced an increase in spontaneous incisor chattering, particularly among males. SKF 83959 induced incisor chattering, vertical jaw movements and tongue protrusions; the level of horizontal jaw movements was increased and that of tongue protrusions decreased in neuregulin-1 'knockouts'. These findings indicate that the schizophrenia risk gene neuregulin-1 is involved in the regulation of not only social behaviour but also orofacial dyskinesia. Orofacial dyskinesia in neuregulin-1 mutants may indicate some modest genetic relationship between risk for schizophrenia and vulnerability to spontaneous movement disorder. |
