| Primary Identifier | MGI:2447407 | Allele Type | Transgenic |
| Attribute String | Inserted expressed sequence | Gene | Tg(Trp53A135V)L2Ber |
| Strain of Origin | CD-1 | Is Recombinase | false |
| Is Wild Type | false |
| description | Lines L1, L2, and L3 were produced. |
| molecularNote | This transgene contains the mouse Trp53 (p53) promoter and an allele of the Trp53 gene that carries a point mutation in codon 135 (Ala135Val). Analysis showed the Trp53 promoter to drive high levels of expression in the spleen, thymus, lymph nodes, and ovaries. Transgenic expression was also detected in the lungs, liver, kidney, testis, and brain, while low levels were detected in skeletal muscle. Expression was undetected in the heart and blood. |
