| First Author | Sakakibara I | Year | 2014 |
| Journal | PLoS Genet | Volume | 10 |
| Issue | 5 | Pages | e1004386 |
| PubMed ID | 24852826 | Mgi Jnum | J:226889 |
| Mgi Id | MGI:5698796 | Doi | 10.1371/journal.pgen.1004386 |
| Citation | Sakakibara I, et al. (2014) Six homeoproteins and a Iinc-RNA at the fast MYH locus lock fast myofiber terminal phenotype. PLoS Genet 10(5):e1004386 |
| abstractText | Thousands of long intergenic non-coding RNAs (lincRNAs) are encoded by the mammalian genome. However, the function of most of these lincRNAs has not been identified in vivo. Here, we demonstrate a role for a novel lincRNA, linc-MYH, in adult fast-type myofiber specialization. Fast myosin heavy chain (MYH) genes and linc-MYH share a common enhancer, located in the fast MYH gene locus and regulated by Six1 homeoproteins. linc-MYH in nuclei of fast-type myofibers prevents slow-type and enhances fast-type gene expression. Functional fast-sarcomeric unit formation is achieved by the coordinate expression of fast MYHs and linc-MYH, under the control of a common Six-bound enhancer. |
