| First Author | Zhang H | Year | 2010 |
| Journal | Neurosci Lett | Volume | 479 |
| Issue | 3 | Pages | 287-91 |
| PubMed ID | 20570603 | Mgi Jnum | J:163022 |
| Mgi Id | MGI:4820912 | Doi | 10.1016/j.neulet.2010.05.082 |
| Citation | Zhang H, et al. (2010) Behavioral evaluation of transgenic mice with CNS expression of IFN-alpha by elevated plus-maze and Porsolt swim test. Neurosci Lett 479(3):287-91 |
| abstractText | Chronic IFN-alpha treatment as an antiviral or anti-cancer therapy can lead to severe psychiatric complications, including depression and anxiety in patients. In many animal models of IFN-alpha-induced behavioral dysfunction, the opposite results have frequently been reported. In an attempt to overcome the limitation of pharmacological studies, IFN-alpha-transgenic mice with CNS-targeted expression of the IFN-alpha transgene were used to study depression and anxiety-like behaviors by Porsolt swim and elevated plus-maze assays, respectively. Interestingly, chronic stimulation of IFN-alpha signaling in mouse brains did not cause depression or anxiety as measured by these tests in comparison with wild-type littermates. This observation suggests that factors other than IFN-alpha may be necessary for the development of psychiatric complications following IFN-alpha therapy in patients. |
