| First Author | Ogura A | Year | 1994 |
| Journal | Nephron | Volume | 68 |
| Issue | 2 | Pages | 239-44 |
| PubMed ID | 7830863 | Mgi Jnum | J:21051 |
| Mgi Id | MGI:69101 | Doi | 10.1159/000188264 |
| Citation | Ogura A, et al. (1994) Hereditary nephrotic syndrome with progression to renal failure in a mouse model (ICGN strain): clinical study. Nephron 68(2):239-44 |
| abstractText | The clinical course of murine hereditary nephrotic syndrome (ICGN strain) was determined by examining 201 animals under different conditions. In the early stage, significant hypoproteinemia and hypoalbuminemia developed (p < 0.001) in parallel with a progressive rise in urinary protein concentration (p < 0.001). In the middle stage, the concentrations of total cholesterol, triglyceride, and beta-lipoprotein markedly increased (p < 0.01, p < 0.001, and p < 0.001, respectively), suggesting that type IIb hyperlipoproteinemia developed as in human nephrotic patients. Systemic edema appeared in 8 of 24 animals. In the terminal stage, both BUN and creatinine values greatly increased (p < 0.001), indicating rapid deterioration of renal function. The present study suggests that ICGN mice could be a useful model to study the pathophysiology of human nephrotic syndrome and its progression to renal failure. |
