| Primary Identifier | MGI:2448241 | Allele Type | Targeted |
| Attribute String | Null/knockout | Gene | Adam12 |
| Transmission | Germline | Strain of Origin | (129X1/SvJ x 129S1/Sv)F1-Kitl<+> |
| Is Recombinase | false | Is Wild Type | false |
| molecularNote | The gene was disrupted by replacement of exon 1 with a PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by RT-PCR analysis of day E14.5 homozygous mutant embryos. Primers directed against the metalloprotease, disintegrin, cysteine-rich, and cytoplasmic domains did not detect any gene expression. |
