| First Author | Masaki M | Year | 2005 |
| Journal | Endocrinology | Volume | 146 |
| Issue | 4 | Pages | 1752-63 |
| PubMed ID | 15637293 | Mgi Jnum | J:107577 |
| Mgi Id | MGI:3621501 | Doi | 10.1210/en.2004-1082 |
| Citation | Masaki M, et al. (2005) Role of meltrin {alpha} (ADAM12) in obesity induced by high- fat diet. Endocrinology 146(4):1752-63 |
| abstractText | Meltrin alpha is a member of the metalloprotease-disintegrin (ADAM) family. In this paper we demonstrate that meltrin alpha is involved in the development of white adipose tissue. Compared with wild-type mice, meltrin alpha(-/-) mice displayed moderate resistance to weight gain induced by a high-fat diet, mainly because of an impaired increase in the number of adipocytes. There was no obvious difference in adipocyte size between wild-type and meltrin alpha(-/-) mice, suggesting normal maturation of adipocytes of the latter under a high-fat diet. Embryonic fibroblasts and stromal-vascular cells lacking meltrin alpha exhibited impaired cell proliferation upon adipogenic stimulation, which was accompanied by moderate defects in adipose differentiation. Addition of culture medium conditioned with wild-type cells in an early phase of adipose differentiation did not restore the defects in the meltrin alpha(-/-) cells. These results uncover the involvement of meltrin alpha in the development of obesity and in adipogenic cell proliferation. |
