| First Author | Burgdorf S | Year | 2007 |
| Journal | Science | Volume | 316 |
| Issue | 5824 | Pages | 612-6 |
| PubMed ID | 17463291 | Mgi Jnum | J:121094 |
| Mgi Id | MGI:3709232 | Doi | 10.1126/science.1137971 |
| Citation | Burgdorf S, et al. (2007) Distinct pathways of antigen uptake and intracellular routing in CD4 and CD8 T cell activation. Science 316(5824):612-6 |
| abstractText | The mechanisms that allow antigen-presenting cells (APCs) to selectively present extracellular antigen to CD8+ effector T cells (cross-presentation) or to CD4+ T helper cells are not fully resolved. We demonstrated that APCs use distinct endocytosis mechanisms to simultaneously introduce soluble antigen into separate intracellular compartments, which were dedicated to presentation to CD8+ or CD4+ T cells. Specifically, the mannose receptor supplied an early endosomal compartment distinct from lysosomes, which was committed to cross-presentation. These findings imply that antigen does not require intracellular diversion to access the cross-presentation pathway, because it can enter the pathway already during endocytosis. |
