| First Author | Kong M | Year | 2004 |
| Journal | Science | Volume | 306 |
| Issue | 5696 | Pages | 695-8 |
| PubMed ID | 15499020 | Mgi Jnum | J:93221 |
| Mgi Id | MGI:3056248 | Doi | 10.1126/science.1100537 |
| Citation | Kong M, et al. (2004) The PP2A-associated protein alpha4 is an essential inhibitor of apoptosis. Science 306(5696):695-8 |
| abstractText | Despite evidence that protein kinases are regulators of apoptosis, a specific role for phosphatases in regulating cell survival has not been established. Here we show that alpha4, a noncatalytic subunit of protein phosphatase 2A (PP2A), is required to repress apoptosis in murine cells. alpha4 is a nonredundant regulator of the dephosphorylation of the transcription factors c-Jun and p53. As a result of alpha4 deletion, multiple proapoptotic genes were transcribed. Either inhibition of new protein synthesis or Bcl-xL overexpression suppressed apoptosis initiated by alpha4 deletion. Thus, mammalian cell viability depends on repression of transcription-initiated apoptosis mediated by a component of PP2A. |
